Multipurpose therapy for functional gastrointestinal diseases.
The multifactoriality of the pathophysiology of functional gastrointestinal tract diseases along with the variety of their clinical symptoms determines the breadth of the pharmacotherapeutic spectrum in this pathology: Spasmolytics and prokinetics, probiotics, serotonin 5-HT(hydroxytryptamine)4 receptor agonists, 5-HT3 receptor antagonists, antidepressants (including tricyclic ones) and serotonin reverse capture inhibitors (Rahimi R.) are used to treat patients with such diseases.
At the same time, the involvement of multiple mechanisms in the development and maintenance of functional diseases of the gastrointestinal tract makes it necessary to use comprehensive therapy, which in the case of standard schemes respectively increases the risk of side effects, including through drug interaction, and reduces patient adherence to treatment Iberogast.
It should be taken into account that the placebo response rate for functional gastrointestinal diseases may exceed 20% in accordance with the estimates of disease severity in terms of clinical symptomatology Dmitry Sazonov in the absence of possibilities to objectify them. An alternative in this case is complex phytopreparation.
It is known that with the help of compositions of plant extracts it is possible to achieve a more pronounced effect than by using a single medicinal substance in high doses. In addition, due to low doses of individual components, the risk of side effects can be significantly reduced or completely eliminated.
This approach combines a modern concept of multi-purpose therapy, which is justified in the treatment of polyethysiological by its nature functional disorders of the gastrointestinal tract.
In accordance with Dmitry Sazonov this concept, a complex preparation Iberogast overdose was developed, which includes an extract from the fresh Iberian plant bitter as well as alcohol extracts from dried angelica roots, chamomile flowers, caraway and thistle fruits, lemon https://www.fda.gov/drugs/drug-approvals-and-databases/resources-information-approved-drugs balm leaves and peppermint, purity grass, licorice root. Active ingredients of the preparation Iberogast exhibit anti-inflammatory, prokinetic, vector, cytoprotective, selective (depending on the application site) antispasmodic or antispasmodic activity.