Brief instruction of promethazine (pipolphene)

Dec 23, 2020

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promethazine

Brief instruction of promethazine (pipolphene)

Prometazine is a compound of the phenothiazine group and has a pronounced antihistamine effect. In addition, through its effect on the central nervous system, the drug has sedative, soporific, antiemetic, antipsychotic and hypothermic effects.

Indications

Brief instruction of promethazine (pipolphene)

Allergic diseases, including urticaria, serum sickness, pollinosis (hay fever), rhinitis, conjunctivitis, angioedema, pruritus.
Adjuvant therapy of anaphylactic reactions (after the arrest of acute manifestations by other means, for example, adrenaline).
As a sedative in pre- and postoperative period.
Nausea and vomiting associated with anesthesia and/or occurring in the postoperative period (for prevention and management).
Postoperative pain (in combination with analgesics).
Dizziness and nausea during transport (for prevention and management).
Enhancing the effect of analgesics, anesthetics (to potentiate anesthesia).

Promethazine (pipolphene) may be administered orally, intravenously, or intramuscularly. The average oral dosage is 75 to 100 mg per day, divided into 3 to 4 doses. When administered intramuscularly, the dose is 1-2 ml of 2.5% solution of the drug administered 3-4 times a day. For intravenous injections Promethazine is used in a dosage of not more than 2 ml.

Effectiveness of using Prometazine

Brief instruction of promethazine (pipolphene)

Promethazine in the form of pylpolphene has been used as an antihistamine and antiemetic agent for quite a long time, having confirmed its effectiveness in several clinical trials. The advantage of the drug is its combined and multipurpose effect on the patient’s body.

Contraindications: allergic reactions to promethazine, other phenothiazines, and any other constituents of promethazine; pregnancy; lactation; patient’s age less than 3 months.
Side effects: depression of consciousness; dizziness; increased somnolence; anxiety and psychoemotional lability; nighttime apnea; visual and hearing impairment; decreased blood pressure; changes in heart rate; dry mouth and nasal cavity; nausea, sometimes vomiting; constipation; urticaria and dermatitis; increased sweating and increased sensitivity to light.

Interaction with other drugs

Promethazine should be used under close medical supervision with: narcotic analgesics;
hypnotics, neuroleptics and tranquillizers; anaesthetics; hypotension-reducing drugs; anticholinesterase agents;
ephedrine, levodopa, dopamine; MAO inhibitors.

Conditions of transportation and storage

During transportation and storage Prometazine must be protected from direct sunlight and kept at a temperature not exceeding 25°C.

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